Mirko Vucinic opened the scoring just after a quarter of an hour, but the real turning point in the match was the dismissal of Alessio Cerci, who saw red for a petulant kick on Martin Caceres after 21 minutes.
The hosts never recovered from the numerical disadvantage, and further goals from Artuo Vidal, Claudio Marchisio, Andrea Pirlo and Simone Padoin rounded off the emphatic win for Antonio Conte's men.
AC Milan continued their battle for the Serie A title on Saturday by claiming a comfortable wins.
Zlatan Ibrahimovic again provided ample inspiration for his side at the Stadio Ennio Tardini, scoring a penalty in the first half to put Milan in the driving seat, before Urby Emanuelson wrapped up the spoils just before the hour mark.
