Lionel Messi scored a record five goals to help Barcelona past Bayer Leverkusen 7-1 in their Champions League clash on Wednesday.
The Catalan giants sealed a 10-2 aggregate victory to advance into the quarter-finals of the European competition.
With Champions League debutant Cristian Tello adding a brace to Messi's brilliant tally.
APOEL Nicosia's dream Champions League run continued after they defeated Lyon 4-3 on penalties in Cyprus on Wednesday.
The hosts won 1-0 in 90 minutes to level the tie 1-1, before extra-time ended goalless, sending the contest to spot-kicks.
The Cypriot outfit advanced 4-3 in the shootout, with Michel Bastos' spot kick saved by APOEL goalkeeper Dionisis Chiotis, sending the underdogs through to the quarter-final stage.
Benfica progressed to the last eight of the Champions League 4-3 on aggregate, thanks to a 2-0 win over Zenit St Petersburg on Tuesday.
After losing the first leg 3-2 in St Petersburg on February 15, a goal from Maxi Pereira moments before half-time and another from Nelson Oliveira in second-half injury time saw Jorge Jesus' men run out comfortable winners in the round-of-16 second leg at Estadio da Luz.
Arsenal came within a goal of producing an incredible Champions League comeback on Tuesday but fell just short by beating AC Milan 3-0.
After losing the first leg of their round-of-16 clash 4-0 at San Siro on February 15, Arsenal needed a miracle at the Emirates Stadium, but first half goals from Laurent Koscielny, Tomas Rosicky and Robin van Persie had them within sight of a stunning upset.
Milan regrouped at the interval, however, and managed to hold out to secure a 4-3 aggregate victory and book their place in the last eight.
