Olivier Pantaloni's side began the night in the relegation places against their more fancied opponents, but stole all three points when French midfielder Andre got a touch on a dangerous ball into the box in the 89th minute.
Lyon held off Lille for a 2-1 win in Ligue 1 despite going down to 10 men on Saturday.
They made a strong start to the match at the Stade de Gerland, with Alexandre Lacazette heading home Mouhamadou Dabo's cross 12 minutes in.
Nolan Roux came close to an equaliser for reigning champions Lille, but it was Lyon who claimed the second goal of the match.
Lacazette pounced on a loose ball from Florent Balmont, feeding Lisandro Lopez, who sent a measured shot beyond Lille goalkeeper Mickael Landreau.
The visitors pulled one back in first-half stoppage time, with Aurelien Chedjou Fongang netting a header after Lyon failed to defend Benoit Pedretti's corner.
Yoan Gouffran and Jaroslav Plasil both scored as Bordeaux ran out 2-0 winners away to Brest.
Brice Dja Djedje's own-goal, together with strikes from Vincent Nogueira and Edouard Butin, helped Sochaux come from behind to beat Evian 3-2 away from home.
Nice managed a 1-1 draw at home to Nancy, after Franck Djadjede cancelled out Daniel George Niculae's opener for the visitors.
Mareque Lucas' own-goal and Innocent Emeghara's effort sealed a 2-0 win for Lorient away to Toulouse.
St Etienne scored twice in the space of five minutes late in the second half as they came from behind to beat Valenciennes 2-1 away from home.
